Reappraising cardiac function with myocardial contraction fraction: normal values, disease detection, and prognostication

We established MCF reference ranges, showing superior performance for detecting early disease and tracking progression compared with LVEF. MCF offers enhanced prognostic utility, complementing established metrics of LV function.

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Publication Details

Journal
European Heart Journal - Cardiovascular Imaging
Published
2026-01-21
DOI
https://doi.org/10.1093/ehjci/jeag019
Primary Topic
Cardiovascular Function and Risk Factors
Type
article
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article

Reappraising cardiac function with myocardial contraction fraction: normal values, disease detection, and prognostication

Jéssica Aparecida Artico, P Kellman, Marianna Fontanna, Derralynn Hughes et al.
European Heart Journal - Cardiovascular Imaging
Cardiovascular Function and Risk Factors
article

Reappraising cardiac function with myocardial contraction fraction: normal values, disease detection, and prognostication

Jéssica Aparecida Artico, P Kellman, Marianna Fontanna, Derralynn Hughes, H Shiwani, Anish Bhuva, G Joy, João B. Augusto, G Captur, Aderonke Abiodun, Charlotte Manisty, Alun David Hughes, Lamia Al Saikhan, Uzma Gul, George D. Thornton, James C Moon, Benjamin Meredith, Sabrina Nordin, Viviana Maestrini, Thomas A Treibel, Rebecca Hughes, Rebecca Kozor, Silvia Castelletti, Rhodri H Davies, Erik Schelbert
article en

Abstract

We established MCF reference ranges, showing superior performance for detecting early disease and tracking progression compared with LVEF. MCF offers enhanced prognostic utility, complementing established metrics of LV function.

European Heart Journal - Cardiovascular ImagingVol. 27(4)
King's College - North Carolina (US), University of Pittsburgh (US), King's College London (GB), Royal North Shore Hospital (AU), The Royal Free Hospital (GB), British Heart Foundation (GB), National Heart, Lung, and Blood Institute (US), Ospedale Santa Maria della Misericordia di Udine (IT), Queen Elizabeth University Hospital (GB), University College London (GB), Misericordia University (US), Imam Abdulrahman Bin Faisal University (SA), University of Glasgow (GB), Sapienza University of Rome (IT)
Reduced inequalities
Openalex Percentile: Top 81%
Cardiovascular Function and Risk Factors
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