Multi-omics reveals the protective mechanisms of Gastrodia elata ethyl acetate extract in vascular dementia
The improvement of cognitive dysfunction in vascular dementia by EEGE is closely associated with its regulation of the IGF1-TREM2 axis and the AMPK-SIRT1-FoxO1-NF-κB pathway, thereby mitigating neuroinflammation. This study provides experimental evidence and a potential mechanistic basis for further exploration of EEGE in VD intervention.
Authors
- Jianghao Cheng (ORCID: https://orcid.org/0000-0002-2805-0128)
- Zhourong Zhao
- Zhuo Zhang (ORCID: https://orcid.org/0000-0002-0596-0807)
- Xiaohua Duan
- Jie Tao
- Tian Xiao
- Jiaoyang Tan
Institutions
- Yunnan University (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-23
- DOI
- https://doi.org/10.3389/fphar.2026.1630783
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00