Dogs with idiopathic epilepsy and focal epileptic seizures lack hilar neuron loss and mossy fiber sprouting of temporal lobe epilepsy

Our study focused on dogs with focal seizures as their main seizure presentation as that is the most common semiology in people with TLE. However, a future study could consider evaluating the neuropathology of dogs with asymmetric hippocampi detected on MRI. If TLE can be shown in dogs, then advanced treatment options, such as surgery or laser ablation, could be considered in refractory patients.