Diagnostic utility of cerebrospinal fluid IgG index, 24-hour IgG synthesis rate, and immunophenotyping in primary central nervous system large B-cell lymphoma: A case report

This case demonstrates the potential of integrating CSF IgG index, 24-hour IgG synthesis rate, and immunophenotyping as reliable, noninvasive diagnostic tools for the early detection of PCNS-LBCL, especially when imaging findings are inconclusive. The approach may offer valuable insights for improving diagnostic accuracy in clinical practice.

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Publication Details

Journal
Medicine
Published
2026-01-23
DOI
https://doi.org/10.1097/md.0000000000047208
Primary Topic
CNS Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Diagnostic utility of cerebrospinal fluid IgG index, 24-hour IgG synthesis rate, and immunophenotyping in primary central nervous system large B-cell lymphoma: A case report

Jing He, Jianguo Wu, Yiqi Yan, Bihua Yao
Medicine
CNS Lymphoma Diagnosis and Treatment
article

Diagnostic utility of cerebrospinal fluid IgG index, 24-hour IgG synthesis rate, and immunophenotyping in primary central nervous system large B-cell lymphoma: A case report

Jing He, Jianguo Wu, Yiqi Yan, Bihua Yao
article en

Abstract

This case demonstrates the potential of integrating CSF IgG index, 24-hour IgG synthesis rate, and immunophenotyping as reliable, noninvasive diagnostic tools for the early detection of PCNS-LBCL, especially when imaging findings are inconclusive. The approach may offer valuable insights for improving diagnostic accuracy in clinical practice.

MedicineVol. 105(4)
Zhejiang Chinese Medical University (CN), First Hospital of Jiaxing (CN), Hangzhou Medical College (CN)
Good health and well-being
Openalex Percentile: Top 81%
CNS Lymphoma Diagnosis and Treatment
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