Diagnostic utility of cerebrospinal fluid IgG index, 24-hour IgG synthesis rate, and immunophenotyping in primary central nervous system large B-cell lymphoma: A case report
This case demonstrates the potential of integrating CSF IgG index, 24-hour IgG synthesis rate, and immunophenotyping as reliable, noninvasive diagnostic tools for the early detection of PCNS-LBCL, especially when imaging findings are inconclusive. The approach may offer valuable insights for improving diagnostic accuracy in clinical practice.
Authors
- Jing He (ORCID: https://orcid.org/0000-0002-4434-2198)
- Jianguo Wu (ORCID: https://orcid.org/0000-0002-8326-2895)
- Yiqi Yan
- Bihua Yao
Institutions
- Zhejiang Chinese Medical University (CN)
- First Hospital of Jiaxing (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Medicine
- Published
- 2026-01-23
- DOI
- https://doi.org/10.1097/md.0000000000047208
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00