Neuroinflammation in <scp>GAD65</scp> Antibody‐Associated Epilepsy Measured Using [ <scp> <sup>18</sup> F </scp> ] <scp>DPA</scp> ‐714 <scp>PET</scp> / <scp>MRI</scp>
The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy is a challenge. We used the translocator protein radioligand [<sup>18</sup>F]DPA-714 and PET to evaluate brain microglial activation. [<sup>18</sup>F]DPA-714 PET brain images of 11 patients with GAD65 antibody-associated epilepsy and seven controls were analyzed. Patients with acute symptomatic seizures presented higher [<sup>18</sup>F]DPA-714 SUVR in the hippocampus than did controls and patients with chronic temporal lobe epilepsy. Our findings highlight that [<sup>18</sup>F]DPA-714 PET/MRI represents a useful tool to assess neuroinflammation in patients with GAD65 antibody-associated epilepsy.
Authors
- Xintong Guo (ORCID: https://orcid.org/0000-0003-1203-7559)
- Guanzhong Ni (ORCID: https://orcid.org/0000-0002-2334-3423)
- Yue Liu (ORCID: https://orcid.org/0000-0002-0084-863X)
- Yicong Liu (ORCID: https://orcid.org/0000-0002-0265-5196)
- Ziyi Chen (ORCID: https://orcid.org/0000-0003-0291-9435)
- Jie Chen (ORCID: https://orcid.org/0000-0003-0266-0929)
- Ningning Wang
- Yuying Zhang
- Heyu Zhang
- Jinming Zhang
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1002/acn3.70324
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China