Reprogramming the epigenetic profile improves the B regulatory cell function of patients with recurrent pregnancy loss
TRIM28 deficiency disrupts DNMT1 degradation, leading to DNMT1-mediated IL10 silencing and Breg dysfunction in RPL. SAHA targets the TRIM28-DNMT1-IL10 axis to restore immune tolerance, representing a precision therapy for immune-mediated RPL.
Authors
- Fei Ma (ORCID: https://orcid.org/0000-0003-0401-0954)
- Ping Tang (ORCID: https://orcid.org/0000-0002-8721-4209)
- Xiaoyang Feng
- Lingzhi Xu
- Qing Xu
- Yan Ning
- Yuanyi Zhang
- Pingchang Yang
- Yanyu Ye
Institutions
- Weifang Medical University (CN)
- Guangzhou University of Chinese Medicine (CN)
- Shenzhen University (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Shenzhen Luohu People's Hospital (CN)
- Southern Medical University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2026-01-23
- DOI
- https://doi.org/10.1186/s12964-026-02669-7
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00