A New λ3-Iodine Reagent: Discovery, Properties, and Application toward Versatile Bond-Forming Reaction

Abstract A newly developed polymeric hypervalent iodine reagent has exhibited unique properties, including enhanced stability, reactivity, and selectivity. These attributes make it a highly versatile tool for synthesizing a wide range of C–N, N–N, and C–C bonds. Its ability to oxidize methanol and DMSO at room temperature opens up new avenues in hypervalent iodine chemistry. The reagent’s efficiency in generating small molecules, such as diaziridines, in situ Mannich bases, under mild conditions showcases its potential as an alternative to traditional metal-catalyzed processes. Additionally, mechanistic insights into gem-diamination, gained through 3D MIR-ATR spectroscopy, lay the foundation for broader applications of this promising reagent in synthetic organic chemistry.