Gut mycobiota dysbiosis and an emergent state of “co-dysbiosis” are associated with IgE sensitization in children with comorbid allergic rhinitis and constipation

This study provides the first evidence that gut mycobiota dysbiosis-marked by depletion of immunoregulatory fungi and an ecological shift toward cooperative interkingdom interactions ("co-dysbiosis")-is associated with IgE sensitization in ARFC children. These findings position the gut mycobiota as a novel element of the gut-nose axis in allergic disease, warranting further investigation.