The Impact of ERAP1 and ERAP2 Haplotype Combinations on Susceptibility and Severity of Birdshot Chorioretinitis
Our findings support a model in which ERAP1 and ERAP2 contribute to BSCR susceptibility, but have limited influence on disease severity. The observed pattern of reduced ERAP1 and elevated ERAP2 activity in BSCR patients may affect peptide processing and HLA-A29-mediated presentation.
Authors
- Thierry Tabary (ORCID: https://orcid.org/0000-0001-6301-589X)
- J. Cohen
- Antoine P. Brézin (ORCID: https://orcid.org/0000-0001-8461-3119)
- Jordan Loeliger (ORCID: https://orcid.org/0000-0001-8826-9730)
- Souhila Kecili
- Dominique Monnet (ORCID: https://orcid.org/0000-0001-6846-6120)
- Xiaodong Bai
- Linda Imikirene
- Eli Stahl
- Sahar Gelfman
Institutions
- Regeneron (United States) (US)
- University Hospital of Basel (CH)
- Assistance Publique – Hôpitaux de Paris (FR)
- Université de Reims Champagne-Ardenne (FR)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-23
- DOI
- https://doi.org/10.1167/iovs.67.1.51
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00