Methylglyoxal‐derived hydroimidazolone ( <scp>MG</scp> ‐ <scp>H1</scp> ) is a novel marker of insulin resistance in Japanese individuals, disturbing insulin signalling via <scp>mTORC2</scp> in cultured myocytes
In clinical study findings revealed that postprandial MG-H1 was a novel marker of insulin resistance in Japanese individuals, and in vitro findings using cultured C2C12 skeletal myocytes suggested that MG-H1 disturbs insulin signalling via the mechanisms of mTORC2 activation.
Authors
- Etsuko Ueta (ORCID: https://orcid.org/0000-0002-2961-6701)
- Tsuyoshi Okura (ORCID: https://orcid.org/0000-0003-3713-6617)
- Junichiro Miake
- Kazuhiko Matsuzawa (ORCID: https://orcid.org/0000-0001-8187-6765)
- Yoshinori Ichihara (ORCID: https://orcid.org/0000-0002-6746-5617)
- Sonoko Kitao
- Yuzuru Otsuka (ORCID: https://orcid.org/0000-0002-0396-3270)
- Shin‐ichi Taniguchi (ORCID: https://orcid.org/0000-0002-1417-8753)
- Yuri Nomi (ORCID: https://orcid.org/0000-0002-8904-061X)
- Satomi Endo
- Takeshi Imamura
- Risa Nakamura
- Tatsuya Sawano
- Yuichi Ito
- Kazuhiro Yamamoto
- Keiko Nagata
Institutions
- Niigata University of Pharmacy and Medical and Life Sciences (JP)
- Ochanomizu University (JP)
- National Cerebral and Cardiovascular Center (JP)
- Tottori University (JP)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2026-01-23
- DOI
- https://doi.org/10.1111/dom.70489
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00