Impaired atrioventricular time interaction contributes to tachycardia-induced hemodynamic deterioration: In vivo and in silico hybrid approach
AV time interaction manifests as E-A wave fusion and decreased LVEDP/LAP ratio. Simulation studies suggest that conditions directly affecting filling time significantly impair AV time interaction and lead to circulatory deterioration during tachycardia. These findings highlight the importance of individualized HR management.
Authors
- Kenta Ohba (ORCID: https://orcid.org/0009-0009-2406-3771)
- Masafumi Fukumitsu (ORCID: https://orcid.org/0000-0002-1419-7217)
- Takuya Nishikawa (ORCID: https://orcid.org/0000-0002-4951-7831)
- Midori Kakuuchi
- Yuki Yoshida (ORCID: https://orcid.org/0000-0002-0185-7554)
- Nana Hiraki (ORCID: https://orcid.org/0009-0001-5577-6549)
- Masahiro Otake (ORCID: https://orcid.org/0009-0002-4938-3738)
- Kazunori Uemura (ORCID: https://orcid.org/0000-0003-2900-4702)
- Kei Sato
- Hidetaka Morita
- Hiroki Matsushita
- Shohei Yokota
- Kengo Kusano
- Keita Saku
- Toru Kawada
Institutions
- National Cerebral and Cardiovascular Center (JP)
Publication Details
- Journal
- International Journal of Cardiology
- Published
- 2026-01-23
- DOI
- https://doi.org/10.1016/j.ijcard.2026.134192
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00