A Study on the Analgesic Effects of Two Different Doses of Morphine Added to Intrathecal Levobupivacaine in Cesarean Section: A Randomized Double-Blind Study

In this study, both 50 µg and 100 µg doses of intrathecal morphine provided effective and safe postoperative analgesia following elective cesarean section. However, the 100 µg dose demonstrated superior analgesia in terms of a reduced requirement for supplemental NSAIDs, rather than a difference in the time to first analgesic request. As this benefit was achieved without an increase in opioid-related side effects, 100 µg of intrathecal morphine may be the preferred dosage for post-cesarean analgesia.

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Publication Details

Journal
Cureus
Published
2026-01-23
DOI
https://doi.org/10.7759/cureus.102133
Primary Topic
Anesthesia and Pain Management
Type
article
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article

A Study on the Analgesic Effects of Two Different Doses of Morphine Added to Intrathecal Levobupivacaine in Cesarean Section: A Randomized Double-Blind Study

Aparna Jarathi, Sandeep Garre, Rama Krishna Prasad Chikkala, Mulam Lakshmi Haritha et al.
Cureus
Anesthesia and Pain Management
article

A Study on the Analgesic Effects of Two Different Doses of Morphine Added to Intrathecal Levobupivacaine in Cesarean Section: A Randomized Double-Blind Study

Aparna Jarathi, Sandeep Garre, Rama Krishna Prasad Chikkala, Mulam Lakshmi Haritha, Syama Sundar Ayya
article en

Abstract

In this study, both 50 µg and 100 µg doses of intrathecal morphine provided effective and safe postoperative analgesia following elective cesarean section. However, the 100 µg dose demonstrated superior analgesia in terms of a reduced requirement for supplemental NSAIDs, rather than a difference in the time to first analgesic request. As this benefit was achieved without an increase in opioid-related side effects, 100 µg of intrathecal morphine may be the preferred dosage for post-cesarean analgesia.

CureusVol. 18(1)
All India Institute of Medical Sciences (IN)
Good health and well-being
Openalex Percentile: Top 80%
Anesthesia and Pain Management
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