Fibrinogen replacement to prevent intracranial hemorrhage in ischemic stroke patients after thrombolysis – a prospective randomized open blinded endpoint trial (FibER): rationale and methods
FibER will determine if early fibrinogen repletion is safe during acute ischemic stroke and prevent bleeding in patients with fibrinogen depletion after IVT for acute ischemic stroke (registered with US National Library of Medicine NCT05300672 and Eudra-CT 2020-005242-41).
Authors
- Flavia Baccari (ORCID: https://orcid.org/0000-0002-2148-9664)
- Sabina Cevoli (ORCID: https://orcid.org/0000-0003-4668-4295)
- Stefano Forlivesi (ORCID: https://orcid.org/0000-0003-0609-3044)
- Laura Vandelli (ORCID: https://orcid.org/0000-0001-8338-0907)
- Francesco Nonino
- Andrea Zini
- Michele Romoli
- Mario Sebastiani
- Elena Merli
- Guido Bigliardi
- Luana Gentile
- Ludovica Migliaccio
Institutions
- Ospedale Maggiore (IT)
- Azienda Unita' Sanitaria Locale Di Modena (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- Ospedale “M. Bufalini” di Cesena (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Ospedale Bellaria (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2026-01-23
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108572
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute