<i>In vitro</i> activity of gepotidacin against a challenging panel of multidrug-resistant <i>Neisseria gonorrhoeae</i> isolates
Overall, gepotidacin was active in vitro against this challenging panel of ceftriaxone-resistant gonococcal clinical isolates. Gepotidacin activity does not seem to be affected in this ceftriaxone-resistant set of strains. A structural analysis suggests that the rare GyrA A92P alteration identified in this study does not affect gepotidacin binding.
Authors
- Michel Doumith (ORCID: https://orcid.org/0000-0002-8004-0314)
- Michaela Day (ORCID: https://orcid.org/0000-0002-5089-2321)
- Charles Jakielaszek (ORCID: https://orcid.org/0000-0003-4839-0266)
- Anna Vickers
- Rachel Pitt (ORCID: https://orcid.org/0000-0002-3524-5935)
- Michelle Cole (ORCID: https://orcid.org/0000-0002-6707-6910)
- Nicole E. Scangarella-Oman (ORCID: https://orcid.org/0000-0003-4211-8261)
- Helen Fifer
Institutions
- National Security Agency (US)
- Infectious Disease Consultants (US)
- Glaxosmithkline (Finland) (FI)
- Public Health Agency (GB)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1093/jac/dkag001
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00