The discordance of remnant cholesterol and low-density lipoprotein cholesterol as a predictor of diabetes, diabetic microvascular diseases, and cardiovascular disease

(1) The discordance between RC and LDL-c is significantly associated with diabetes, diabetic microvascular diseases, and cardiovascular disease. (2) In NHANES, the RCS analysis showed linear relationships for diabetes, DKD, DR and CVD. In clinical cohort, the RCS analysis showed linear relationships for diabetes and non-linear for CVD. (3) The association of discordance with diabetes, DKD and CVD was more prevalent in individuals with hypertension and HOMA-IR ≥3.1, while individuals with hypertension were more sensitive to DR and individuals with HOMA-β <100 were more sensitive to diabetes. (4) The discordance showed the certain predictive ability for all outcomes.