1,2-Cyclic acetal-type glycerophospholipids from the arctic starfish <i>Asterias microdiscus</i>
Unusual 1,2-cyclic acetal-type glycero-3-phosphoethanolamines, isolated from the EtOH extract of the Arctic starfish <i>Asterias -microdiscus</i> (Chukchi Sea), were analysed as constituents of a RP-HPLC fraction using extensive NMR, MS techniques, and chemical transformations. Four new ethanolamine glycerophospholipids were found to differ from each other in the positions of - CH = CH - CH(OOH/OH)- moieties in linear acetal-linked C<sub>20</sub> chains. The mixture of these compounds showed cardioprotective activity against CoCl<sub>2</sub>-induced damage of H9c2 cardiomyocytes <i>via</i> partial restoration of mitochondrial membrane potential.
Authors
- Ekaterina A. Yurchenko (ORCID: https://orcid.org/0000-0001-7737-0980)
- Alla A. Kicha (ORCID: https://orcid.org/0000-0002-1371-0103)
- Natalia V. Ivanchina (ORCID: https://orcid.org/0000-0001-9075-8584)
- T. B. Malyarenko
- Anatoly I. Kalinovsky
- Valentin A. Stonik
- Roman S. Popov
- Elena A. Santalova
Institutions
- Far Eastern Federal University (RU)
- Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences (RU)
Publication Details
- Journal
- Natural Product Research
- Published
- 2026-01-23
- DOI
- https://doi.org/10.1080/14786419.2026.2619416
- Primary Topic
- Echinoderm biology and ecology
- Type
- article
- Field-Weighted Citation Impact
- 0.00