The protective role of CD44 and microRNA-146a in tendinopathy
This study highlights the protective role of the CD44-AKT-miR-146a axis in tendinopathy. By modulating the AKT/miR-146a/Smad4 signalling pathway, CD44 and miR-146a effectively reduce apoptosis in tendinopathic tenocytes and tendons.
Authors
- P.-S. Wu
- Po-Yen Ko (ORCID: https://orcid.org/0000-0001-7924-5497)
- I-Ming Jou (ORCID: https://orcid.org/0000-0001-8809-028X)
- Che-Chia Hsu (ORCID: https://orcid.org/0000-0002-4194-0686)
- Woei-Jer Chuang
- Shih-Yao Chen
- Hung-Wei Yang
Institutions
- Chung Hwa University of Medical Technology (TW)
- E-Da Hospital (TW)
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
- I-Shou University (TW)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2026-01-23
- DOI
- https://doi.org/10.1302/2046-3758.151.bjr-2024-0475.r2
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AO Foundation
- National Cheng Kung University Hospital
- National Cheng Kung University
- National Science and Technology Council