Dapagliflozin lowers blood pressure via regulating the sympathetic neural activity in the paraventricular nucleus of hypothalamus in normal mice
DAPA, as an SGLT-2 inhibitor, crosses the BBB and binds to the innate SGLT-2 in the hypothalamus and brainstem of mice. This significantly influences the tone of the SNS through indirect regulation by modulating nNOS, CRH, and VP, which are believed to be the upstream regulatory points of SGLT-2 in interacting with the SNS.
Authors
- Meiyuan Dong (ORCID: https://orcid.org/0000-0002-2897-9316)
- Ligang Zhou (ORCID: https://orcid.org/0009-0006-1617-5296)
- Zhimin Xu
- Song Wen
Institutions
- Fudan University (CN)
- Pudong Medical Center (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-23
- DOI
- https://doi.org/10.3389/fendo.2026.1689167
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00