Hypoxic glycolysis-driven histone lactylation activates NHE7 to promote endometrial cancer progression via COX6C-mediated endoplasmic reticulum stress
Hypoxia-driven glycolysis induces histone lactylation, leading to the upregulation of NHE7 expression. This process enhances OXPHOS-induced ER stress by upregulating COX6C expression, ultimately contributing to the malignant progression of EC.
Authors
- Linhua Qian
- T. Wang
- Yuejiang Ma
- Shizhou Yang
- Tingting Wu (ORCID: https://orcid.org/0000-0003-4375-6820)
- Zhu Cao
- Zhengyun Chen
- Xiufeng Huang
Institutions
- Zhejiang Lab (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
Publication Details
- Journal
- APOPTOSIS
- Published
- 2026-01-23
- DOI
- https://doi.org/10.1007/s10495-026-02262-w
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhejiang University
- Natural Science Foundation of Zhejiang Province