MicroRNA profiling in post-mortem spinal cord of C9ORF72-related ALS patients reveals molecular pathways involved in motor neuron degeneration
This study identifies specific miRNAs and their target genes as key molecules in motor neuron degeneration in C9ORF72-ALS. Restoring their expression could represent a therapeutic approach for ALS.
Authors
- V. Pensato
- Stefania Marcuzzo (ORCID: https://orcid.org/0000-0001-6893-6372)
- Paola Ferreira Cavalcante
- G. Marucci
- Claudia Malacarne (ORCID: https://orcid.org/0000-0001-9208-021X)
- Cinzia Gellera
- Samanta Mazzetti (ORCID: https://orcid.org/0000-0002-2944-8357)
- Eleonora Giagnorio (ORCID: https://orcid.org/0000-0001-5226-1593)
- M. Marcuzzo
- Marco Cattaneo (ORCID: https://orcid.org/0009-0004-6085-3280)
- Salvi Erika
- Giorgia Farinazzo
- Emanuela Maderna
- Silvia Bonanno
Institutions
- University of Milan (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Politecnico di Milano (IT)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-01-23
- DOI
- https://doi.org/10.3389/fnins.2026.1741065
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Ministero della Salute