Single-cell transcriptomics reveals keratinocyte dynamic processes associated with S100a4 expression in psoriasiform dermatitis
Our findings suggest a potential pathogenic role for S100A4 in psoriasis and highlight previously uncharacterized cell-specific transcriptional landscapes and regulatory mechanisms. Our results provide novel insights into the complex pathology of psoriasis and could offer important clues for the development of new targeted therapeutic strategies.
Authors
- Weidong Wu (ORCID: https://orcid.org/0000-0001-9903-7185)
- DeZhi Zhang
- Tingting Li (ORCID: https://orcid.org/0009-0005-9090-1324)
- Huiqin Wang (ORCID: https://orcid.org/0000-0002-7010-197X)
- Yiqi Wang
- Zhenqun Weng
- Caying Wu
- Yuan Ding
- Shirong Yu
- Yaqin Ma
Institutions
- Xinjiang Production and Construction Corps (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1744860
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Xinjiang