Shared autonomic phenotype of long COVID and myalgic encephalomyelitis/chronic fatigue syndrome
Both Long COVID and ME/CFS demonstrate dysregulation in cerebrovascular blood flow, autonomic reflexes, and small fiber neuropathy, suggesting that these conditions may share a common underlying pathophysiology. However, differing distributions of findings in patients with hEDS raise the question of whether these conditions represent distinct but overlapping syndromes or reflect a shared underlying pathway. Further research is required to clarify the relationship between these conditions and the potential underlying pathophysiological mechanisms.
Authors
- Donna Felsenstein
- Joël Krier
- Sadie Marciano
- David M. Systrom (ORCID: https://orcid.org/0000-0002-9610-6330)
- Alexandra Witte (ORCID: https://orcid.org/0000-0002-1529-7551)
- Aubrey Milunsky
- Mark C. Fishman
- Peter Novak
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Massachusetts General Hospital (US)
- Radius Health (United States) (US)
- Center for Human Genetics (US)
- Regenerative Medicine Institute (MX)
- Harvard Stem Cell Institute (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-23
- DOI
- https://doi.org/10.1371/journal.pone.0341278
- Citations
- 1
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 33.12
Funders
- Dysimmune Diseases Foundation
- Foundation for Biomedical Research and Innovation
- National Heart, Lung, and Blood Institute