SPIB suppresses protective autophagy via the IFIT2/PINK1/Parkin axis to promote anoikis in colorectal cancer
Our results demonstrate that SPIB exerts tumor-suppressive effects during CRC invasion and metastasis through the IFIT2/PINK1/Parkin axis. This study highlights SPIB as a potential therapeutic target for overcoming anoikis resistance in CRC therapy.
Authors
- Qican Deng
- Zhongxue Fu (ORCID: https://orcid.org/0000-0001-8160-2975)
- Zhenzhou Chen (ORCID: https://orcid.org/0000-0002-4324-5388)
- Yajun Chen
Institutions
- Army Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1186/s12935-026-04185-7
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00