Oxytocin Receptor Polymorphism rs53576 Is Linked to Habitual Alcohol and Sucrose Intake, as well as Liver Steatosis, in a General Japanese Population Cohort
These findings indicate that the OXTR rs53576 polymorphism is associated with distinct alcohol and sucrose intake patterns and susceptibility to liver steatosis, supporting the potential for genotype-informed nutritional interventions aimed at reducing the risk of AUD, ALD, and metabolic dysfunction-associated steatotic liver disease.
Authors
- Yujiro Nakano (ORCID: https://orcid.org/0000-0003-1620-7164)
- Kazuyoshi Hosomichi (ORCID: https://orcid.org/0000-0003-2712-1825)
- Toshinari Takamura (ORCID: https://orcid.org/0000-0002-4393-3244)
- Takehiro Sato (ORCID: https://orcid.org/0000-0001-9866-0346)
- Hiromasa Tsujiguchi (ORCID: https://orcid.org/0000-0001-7511-0165)
- Hisanori Goto (ORCID: https://orcid.org/0009-0008-4723-6156)
- A. Hara
- Takayuki Kannon (ORCID: https://orcid.org/0000-0001-9866-1621)
- Yumie Takeshita
- Hiroyuki Nakamura
- Atsushi Tajima
- Yasuhiko Yamamoto
- Shigeru Yokoyama
Institutions
- Kanazawa University (JP)
- Fujita Health University (JP)
- Tokyo University of Pharmacy and Life Sciences (JP)
- Kanazawa Medical University (JP)
- University of the Ryukyus (JP)
Publication Details
- Journal
- Journal of Nutrition
- Published
- 2026-01-23
- DOI
- https://doi.org/10.1016/j.tjnut.2026.101375
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00