A gut microbiota–stem cell axis mediates the anti‐intestinal aging effect of fucoidan from <scp> <i>Apostichopus japonicus</i> </scp>
Aj-FUC mitigates intestinal aging primarily by modulating the gut microbiota and subsequently promoting ISC-mediated epithelial renewal via the Wnt/β-catenin pathway. These findings highlight the promise of Aj-FUC as a marine-based prebiotic functional food ingredient for improving intestinal health during aging. © 2026 Society of Chemical Industry.
Authors
- Biqian Wei
- Houyang Sun
- Qingjuan Tang
- Tiantian Zhang
- Simin He
- Yaoguang Chang
- Shaoli Song
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Journal of the Science of Food and Agriculture
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1002/jsfa.70471
- Primary Topic
- Seaweed-derived Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00