Cross-organ single-cell integration identifies liver-specific fibroblast programs and HGF-MET/AGT-AGTR1B axes that link fibrosis to hepatocarcinogenesis.

Cross-organ single-cell integration prioritizes liver-selective stromal circuitry and nominates hepatocyte-FB axes (HGF-MET, AGT-AGTR1B) as plausible links between fibrogenic remodeling and a pro-tumorigenic niche, yielding testable hypotheses at the interface of regeneration, RAS biology, and tumor initiation.

Authors

Institutions

Publication Details

Journal
PubMed
Published
2025-12-29
Primary Topic
Liver physiology and pathology
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Cross-organ single-cell integration identifies liver-specific fibroblast programs and HGF-MET/AGT-AGTR1B axes that link fibrosis to hepatocarcinogenesis.

Shuna Zhang, Xin Li, Pei Sun
PubMed
Liver physiology and pathology
article

Cross-organ single-cell integration identifies liver-specific fibroblast programs and HGF-MET/AGT-AGTR1B axes that link fibrosis to hepatocarcinogenesis.

Shuna Zhang, Xin Li, Pei Sun
article en

Abstract

Cross-organ single-cell integration prioritizes liver-selective stromal circuitry and nominates hepatocyte-FB axes (HGF-MET, AGT-AGTR1B) as plausible links between fibrogenic remodeling and a pro-tumorigenic niche, yielding testable hypotheses at the interface of regeneration, RAS biology, and tumor initiation.

PubMedVol. 46(7)
Beijing Ditan Hospital (CN)
Good health and well-being
Openalex Percentile: Top 27%
Liver physiology and pathology
OpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Cross-organ single-cell integration identifies liver-specific fibroblast programs and HGF-MET/AGT-AGTR1B axes that link fibrosis to hepatocarcinogenesis. — Shuna Zhang, Xin Li, et al. · PubMed (2025) | TGRS Research Map | TGRS