Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition

Later mortality in children recovering from CSM is associated with persistent immune activation, a sepsis-like phenotype involving multiple systems. These findings suggest that children at risk of later mortality may benefit from biomarker-guided interventions initiated at discharge.

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Publication Details

Journal
BMC Medicine
Published
2026-01-22
DOI
https://doi.org/10.1186/s12916-026-04647-9
Primary Topic
Child Nutrition and Water Access
Type
article
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article

Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition

Laura Mwalekwa, Bonface M. Gichuki, James M. Njunge, Moses Mukaba Ngari et al.
BMC Medicine
Child Nutrition and Water Access
article

Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition

Laura Mwalekwa, Bonface M. Gichuki, James M. Njunge, Moses Mukaba Ngari, Brenda Kamau, Cecillia Wechessa, Johnstone Thitiri, Evans O. Mudibo, James A. Berkley, Elisha Omer, David M. Mburu
article en

Abstract

Later mortality in children recovering from CSM is associated with persistent immune activation, a sepsis-like phenotype involving multiple systems. These findings suggest that children at risk of later mortality may benefit from biomarker-guided interventions initiated at discharge.

BMC MedicineVol. 24(1)
Wellcome/MRC Cambridge Stem Cell Institute (GB), Pwani University (KE), Angkor Hospital for Children (KH), Nairobi Hospital (KE), Wellcome Sanger Institute (GB), Kenya Medical Research Institute (KE), The Childhood Acute Illness and Nutrition Network (KE), Wellcome Trust (GB), Wageningen University & Research (NL)
Zero hunger
Openalex Percentile: Top 80%
Child Nutrition and Water Access
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Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition — Laura Mwalekwa, Bonface M. Gichuki, et al. · BMC Medicine (2026) | TGRS Research Map | TGRS