Blood DNA methylation markers are associated with diabetic kidney disease progression in type 1 diabetes
The current study detected 11 loci associated with DKD progression, identifying methylation changes predictive of early-stage DKD progression in type 1 diabetes for the first time. Future research is needed to establish prognostic DNA methylation markers for DKD progression.
Authors
- Z. Chen
- Emma Dahlström
- Rama Natarajan (ORCID: https://orcid.org/0000-0003-4494-1788)
- Claire Hill (ORCID: https://orcid.org/0000-0002-2481-5162)
- J. C. Florez
- Alexander P. Maxwell (ORCID: https://orcid.org/0000-0002-6110-7253)
- Niina Sandholm
- Amy Jayne McKnight
- Stefan Mutter
- Laura J. Smyth
- Joel N. Hirschhorn
- the FinnDiane Study Group
- Valma Harjutsalo
- Per-Henrik Groop
- Anna Syreeni
- Andrzej S. Krolewski
Institutions
- Broad Institute (US)
- Queen's University Belfast (GB)
- Boston Children's Hospital (US)
- Joslin Diabetes Center (US)
- University of Helsinki (FI)
- Harvard University (US)
- Baker Heart and Diabetes Institute (AU)
- Helsinki University Hospital (FI)
- Massachusetts General Hospital (US)
- City of Hope (US)
- Institute for Molecular Medicine Finland (FI)
- Folkhälsans Forskningscentrum (FI)
- Monash University (AU)
Publication Details
- Journal
- Diabetologia
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1007/s00125-025-06661-7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Scholarship Council