AAV-DJ–Mediated <i>MYOC</i> Silencing as a Gene Therapy Approach for Myocilin-Associated Glaucoma
AAV-DJ-mediated MYOC silencing effectively alleviated glaucomatous pathology in Tg-MYOCP370L mice, highlighting its potential as a gene therapy strategy for myocilin-associated glaucoma.
Authors
- Luyi Han (ORCID: https://orcid.org/0000-0003-4046-2763)
- Shen Wu (ORCID: https://orcid.org/0009-0007-2981-9123)
- Jiaxiang Zhang (ORCID: https://orcid.org/0000-0002-8951-1469)
- Yufei Teng
- Xiangxiang Liu
- Yue Wan
- Xuejing Yan
- Ningli Wang
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Henan Academy of Sciences (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1167/iovs.67.1.48
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00