Ramulus mori (Sangzhi) alkaloids improve intestinal oxidative damage and inflammation in DHEA-induced polycystic ovary syndrome rats via gut microbiota and metabolite modulation
Collectively, these findings indicate that SZ-A alleviates PCOS by attenuating intestinal oxidative stress and normalizing gut microbiota-metabolite interactions, and highlight fenoldopam as a potential effector, supporting SZ-A as a promising therapeutic candidate for PCOS.
Authors
- Wu Sx
- Biao Huang (ORCID: https://orcid.org/0000-0002-5005-6980)
- Ling Yao
- Shan Geng (ORCID: https://orcid.org/0000-0003-0838-4726)
- Xing Wen (ORCID: https://orcid.org/0000-0003-4431-7539)
- Li Jian
- Xianmei Jiang
- Yong Cai
- Yu Yang
- Qiaohui Wang
- Dan Zuo
- Yanping Wang
Institutions
- Chongqing Academy of Chinese Materia Medica (CN)
- Chongqing Dazu District People's Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fphar.2025.1701694
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chongqing Science and Technology Commission
- Chongqing Medical University
- Chongqing Municipal Education Commission
- Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission