K+ channel blockade limits AF and suppresses phase 3 EADs by slowing repolarization in an electromechanical cell computational model
In both types of EAD, a shorter, Ca<sup>2+</sup>-desensitized sarcomere can reduce the propensity for AF in the model. In general, K<sup>+</sup> channel blockade has anti-arrhythmic potential to suppress phase 3 EADs by slowing repolarization.
Authors
- Stefano Severi (ORCID: https://orcid.org/0000-0003-4306-8294)
- Fazeelat Mazhar (ORCID: https://orcid.org/0000-0002-0466-6825)
- Chiara Bartolucci
Institutions
- Marconi University (IT)
- Laboratori Guglielmo Marconi (Italy) (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fphys.2025.1704051
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00