Activated notch signaling pathway protects the intestinal barrier in DSS-induced colitis by regulating tight junctions
Activation of Jag1/Notch1/Hes1 signaling pathway protects the intestinal mucosal barrier from inflammatory injury by abrogating MLCK-dependent TJ dysregulation.
Authors
- Yanni Li (ORCID: https://orcid.org/0000-0002-3924-8535)
- Tingting Li (ORCID: https://orcid.org/0000-0001-7815-4622)
- Chong Geng
- Xiao Li
- Chunhui Wang
- Shuailing Song
Institutions
- Sichuan University (CN)
- Soochow University (CN)
- West China Hospital of Sichuan University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1186/s40001-026-03941-9
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province