Development and Characterization of a Novel Chronic Thromboembolic Pulmonary Hypertension Rat Model: Identifying Sell-Podxl as Potential Regulators
Our new model recapitulates human chronic thromboembolic pulmonary hypertension pathophysiology and is useful for understanding pulmonary microvasculopathy. Sell-Podxl is a previously unrecognized link between inflammation and vascular remodeling, offering a potential therapeutic target.
Authors
- Yufei Hu (ORCID: https://orcid.org/0009-0005-1114-9489)
- Han Tian
- Ximei Niu (ORCID: https://orcid.org/0009-0005-3899-1908)
- Xincheng Li (ORCID: https://orcid.org/0009-0009-2806-9644)
- Peiran B Yang (ORCID: https://orcid.org/0000-0002-4635-1215)
- Jixiang Liu (ORCID: https://orcid.org/0000-0001-6904-320X)
- Huang Qy
- Ziyi Chang
- D. Wang
- Jie Yang (ORCID: https://orcid.org/0000-0003-4801-7162)
- Lu Sun
- Wenyi Pang
- Yunxia Zhang (ORCID: https://orcid.org/0000-0002-5312-6411)
- Wanmu Xie
- Wanlu Song
- Shuai Zhang
- Min Liu
- Hong Zhang
- Zhenguo Zhai
- Qian Gao
- Ran Miao
- Zhu Zhang
- Zifeng Xu
- Lin Hou
Institutions
- Xinjiang Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- China-Japan Friendship Hospital (CN)
- Beijing Jishuitan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Tumor Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25589
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00