650 nm red-light therapy attenuates sepsis-induced acute lung injury via adiponectin-mediated immune–metabolic reprogramming
Septic ALI modulated by 650 nm PBM was characterized by suppressing CCR2<sup>+</sup> inflammatory recruitment, enriching CX3CR1<sup>+</sup>/M2-like macrophages, and preserving mitochondrial function through adiponectin-AdipoR1 signaling. These data position red-light PBM as a mechanistically grounded, non-invasive method for sepsis-associated lung injury.
Authors
- Jiadie Wang
- Zhixuan Jiang (ORCID: https://orcid.org/0009-0000-4434-8816)
- Jing Yuan (ORCID: https://orcid.org/0000-0002-0058-5542)
- Wei Ni (ORCID: https://orcid.org/0000-0003-3494-9217)
- Yubing Bai
- Min Yao
- Yafeng Li (ORCID: https://orcid.org/0000-0003-0781-347X)
- Yier Bai
- Yiqiu Zhang
- Yu He
- Jianghan Li
Institutions
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fimmu.2026.1710363
- Primary Topic
- Laser Applications in Dentistry and Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00