Transcriptomic analysis reveals the molecular mechanisms of methylene blue-mediated photodynamic therapy against Microsporum canis
Our findings suggest that MB-PDT exerts its antifungal effect against M. canis through a multi-target mechanism that overwhelms cellular repair systems, ultimately triggering the initiation of PCD. This mode of action may mitigate the risk of resistance development, underscoring MB-PDT as a potent therapeutic alternative for the management of dermatophytosis.
Authors
- Xu Weilun
- Qin Shulei
- Zhou Junmeng
- Kaisu Pan
- Dongyan Zheng
- Lan Huang
- Xinyu Zhang
- Peng Gaoyuan
Institutions
- First Affiliated Hospital of GuangXi Medical University (CN)
- Guangxi Center for Disease Prevention and Control (CN)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1016/j.pdpdt.2026.105364
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00