Manifold hepatoprotective actions of α-lipoic acid on metabolic function through redox regulation, inflammatory modulation, and anti-apoptosis after chronic sleep-deprived injury
These findings clearly demonstrate that ALA confers manifold hepatoprotective effects against CSD-induced dysfunction by significantly restoring redox balance, decreasing hepatic inflammation, suppressing apoptotic and ferroptotic signaling, thereby successfully preserving metabolic activity.
Authors
- Ting-Yi Renn
- Kai-Jung Yen
- М. А. Тихонова (ORCID: https://orcid.org/0000-0002-4265-8981)
- Tamara G. Amstislavskaya (ORCID: https://orcid.org/0000-0002-2656-8687)
- Yucheng Liu (ORCID: https://orcid.org/0000-0002-9548-1948)
- Sandeep Kumar Singh (ORCID: https://orcid.org/0000-0002-0022-6240)
- Chang Hm
- Chih-Kai Liao
- Li-You Chen
Institutions
- Neurosciences Institute (US)
- Chung Shan Medical University Hospital (TW)
- Wan Fang Hospital (TW)
- Taipei Medical University (TW)
- Feng Chia University (TW)
- All India Institute of Medical Sciences (IN)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fnut.2025.1679494
- Primary Topic
- Biochemical Acid Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taipei Medical University
- Chung Shan Medical University
- National Science and Technology Council