The shapes of brain waste: Mysteries of cellular remnant morphology in neurodegeneration

This meditation with apologies by a psychiatrist who is not a neuropathologist but attends CPCs of movement disorder patients speculates about how microscopic mechanical processes produce the variety of cellular neuropathological forms, which differ with diagnoses, and wonders what may be revealed by the shapes of these traces by future neuropathologists. New discoveries about tiny machines, nanotubules and the like only increase the intrigue and possibilities of revelations, likened to a crime scene investigation.

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Publication Details

Journal
PubMed
Published
2025-10-18
DOI
https://doi.org/10.17879/freeneuropathology-2026-9059
Primary Topic
Neurology and Historical Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

The shapes of brain waste: Mysteries of cellular remnant morphology in neurodegeneration

David V. Forrest
PubMed
Neurology and Historical Studies
article

The shapes of brain waste: Mysteries of cellular remnant morphology in neurodegeneration

David V. Forrest
article en

Abstract

This meditation with apologies by a psychiatrist who is not a neuropathologist but attends CPCs of movement disorder patients speculates about how microscopic mechanical processes produce the variety of cellular neuropathological forms, which differ with diagnoses, and wonders what may be revealed by the shapes of these traces by future neuropathologists. New discoveries about tiny machines, nanotubules and the like only increase the intrigue and possibilities of revelations, likened to a crime scene investigation.

PubMedVol. 7
Columbia University (US)
Peace, Justice and strong institutions
Openalex Percentile: Top 35%
Neurology and Historical Studies
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The shapes of brain waste: Mysteries of cellular remnant morphology in neurodegeneration — David V. Forrest · PubMed (2025) | TGRS Research Map | TGRS