Relation between obesity and diabetic nephropathy among patients with type 2 diabetes

Objective: The most frequent consequence of diabetes mellitus (DM) is diabetic nephropathy (DN), and obesity is a prominent risk factor for DM.This cross-sectional study aimed to investigate the relationship between obesity and diabetic nephropathy in patients with type 2 diabetes mellitus (T2DM).Methods: This cross-sectional retrospective study included 60 patients with T2DM (32 men and 28 women) aged 44 to 86 years (mean age 62.0 (10.0) years).Those patients included who have had T2DM for more than five years.Anthropometric parameters measured included body mass index (BMI), blood pressure (BP), and blood tests for glucose, glycosylated hemoglobin (HbA1C), total cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL).The severity of diabetic nephropathy was assessed by the level of microalbuminuria in urine excretion.The patients were categorized into two groups: those with obesity (BMI 30 kg/m2) and those without (BMI < 30 kg/m 2 ).Results: The prevalence of microalbuminuria increased (p<0.05) in type 2 diabetic patients with a BMI 30 kg/m.We frequently observe elevated BP, triglycerides, total cholesterol, low HDL-and high LDL in patients with T2DM who have a BMI greater than 30 kg/m compared with those who have a BMI less than 30 kg/m. Conclusion:The development of diabetic nephropathy is significantly influenced by obesity in T2DM.However, in our investigation, no meaningful relation was found between HbA1c, lipid profile, and DN.