Age-related changes in circulating immune factors reveal biomarkers of immunosenescence
sPD-1, IL-6, and sCD28 are associated with immunosenescence and have diagnostic potential, with IL-6 showing the highest individual efficacy. Importantly, their combined detection enhances diagnostic accuracy for immunosenescence, highlighting their synergistic predictive value for immune aging.
Authors
- Lu Ye (ORCID: https://orcid.org/0000-0002-7816-860X)
- Minjie Zhang
- Xin Zhang
- Yifeng Jin
- Jingping Yin
- Jie Li
- Shenjie Xu
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fmed.2026.1729112
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province