Alkyl polyglucoside-enhanced homogenate-ultrasound synergy for multiobjective extraction of polyphenols and pectin from Cotoneaster integerrimus

A homogenization-based method was developed to separate pulp from Cotoneaster integerrimus fruit, demonstrating advantages over conventional separation techniques. Single-factor experiments, guided by the analytic hierarchy process (AHP) and entropy weight method (EWM), evaluated the effects of surfactant and organic acid type and dosage, liquid–solid ratio, ultrasound power and time, and system temperature on the extraction of chlorogenic acid, procyanidin B 2 , epicatechin, hyperoside, and pectin. The Box–Behnken design (BBD) was applied using the ST-score as a composite response index. Optimal extraction conditions included a homogenization speed of 18,000 r/min, 15 s homogenization, 0.60% APG06, 0.09 mol/L oxalic acid, a 25 mL/g liquid–solid ratio, 190 W ultrasound power, 23.5 min irradiation, and 50°C. The optimized parameters yielded high levels of chlorogenic acid (18.36 ± 0.82 mg/g·DW), procyanidin B 2 (69.14 ± 0.76 mg/g·DW), epicatechin (28.26 ± 1.17 mg/g·DW), hyperoside (21.03 ± 0.62 mg/g·DW), and pectin (37.31 ± 0.20 mg/g·DW), with an overall ST-score of 98.45. Compared with microwave-assisted extraction, the method offered cleaner extracts and preserved seed integrity, achieving consistency between subjective and objective evaluations. • Homogenization-ultrasound synergy efficiently separated C. integerrimus pulp • Use response surface via analytic hierarchy process-entropy weight method (AHP-EWM) • Hexyl glucoside was first added to extract five key bioactive components • The method demonstrated superior extraction efficiency and analytical outcomes