Linalool disrupts Escherichia coli biofilms via dual suppression of motility and adhesion
As a low-toxicity phytochemical, linalool exhibits a dual-action mechanism in inhibiting <i>E. coli</i> D5 biofilm formation by suppressing motility and blocking adhesion, representing a potent multitarget agent against biofilm-associated infections. Future studies should validate its pharmacodynamics and potential synergies with conventional antibiotics to facilitate clinical application.
Authors
- Lei Wei (ORCID: https://orcid.org/0000-0002-2263-7681)
- Guowei Xu
- Liping Huang
- Long Wang
- Lei Wang
- Jianxi Li
- Jingyan Zhang
- Jiamian Wang
- Zhiting Guo
- Kang Zhang
Institutions
- Lanzhou Institute of Husbandry and Pharmaceutical Sciences (CN)
- National Quality Inspection and Testing Center for Surveying and Mapping Products (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fvets.2025.1728048
- Citations
- 1
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 22.24