Exploring the <i>in vitro</i> urease inhibitory potential, molecular docking and dynamics simulations investigation of mefenamic acid derivatives
This work identifies <b>2a</b> as a potent, and competitive urease inhibitor. The integrated experimental, ADMET and computational strategy provides a robust molecular blueprint for its activity, positioning it as a promising lead candidate for developing new therapeutic agents against urease-related pathologies.
Authors
- Obaid Ullah (ORCID: https://orcid.org/0000-0001-7388-4888)
- Najeeb Ur Rehman (ORCID: https://orcid.org/0000-0002-1563-225X)
- Ahmed A. Elhenawy (ORCID: https://orcid.org/0000-0003-2893-0376)
- M. Sohail Ahmad
- Aftab Alam
- Atta Ullah
- Ahmed Al-Harrasi
- Ajmal Khan
- Mumtaz Ali
- Muhammad Ayaz
Institutions
- Rawalpindi Medical University (PK)
- University of Nizwa (OM)
- Al-Azhar University (ID)
- Rawalpindi Women University
- Al Baha University (SA)
- University of Malakand (PK)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1080/17568919.2026.2619465
- Primary Topic
- Microbial Applications in Construction Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00