Joint association of estimated glucose disposal rate and aggregate index of systemic inflammation with mortality in general population: a nationwide prospective cohort study
In a nationally representative U.S. cohort, eGDR and log₂(AISI) were independently and jointly associated with all-cause and CVD mortality. Their combined assessment improves risk stratification and may help identify individuals most likely to benefit from targeted preventive and anti-inflammatory strategies.
Authors
- He Yuan
- Yao Zhao
- Siyi Tang
- Chendie Yang
- Fenghua Ding (ORCID: https://orcid.org/0000-0001-9507-4704)
- Ruiyan Zhang
- Ruosen Yuan
- Xiaoqun Wang
- Shuo Feng
Institutions
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Changhai Hospital (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1186/s12933-025-03073-0
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00