Effects and mechanisms of iron overload on the proliferation and differentiation of preosteoblastic cells via a 3D microsphere culture system
The GelMA microsphere-based 3D system provides a physiologically relevant model for studying iron overload. These findings offer not only mechanistic insights but also suggest potential microenvironment-targeted therapeutic strategies for iron overload-associated osteoporosis.
Authors
- Chengdong Zhang (ORCID: https://orcid.org/0000-0002-1100-2584)
- Xiaoman Luo (ORCID: https://orcid.org/0000-0001-9987-1399)
- Gang Feng (ORCID: https://orcid.org/0000-0002-2814-4319)
- Dongqin XIAO
- Xiaojing Luo
- Yu Pan
- Renfeng Zhao
Institutions
- North Sichuan Medical University (CN)
- University of Electronic Science and Technology of China (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fbioe.2026.1700858
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China