Microbial Metabolite 4EPS Inhibits AT1R to Reduce Blood Pressure and Aortic Aneurysm Outcome
These findings identify 4EPS as a benign, endogenous AT1R antagonist that diminishes AngII-mediated hemodynamic and vascular pathology. By suppressing cytoskeletal signaling associated with vascular remodeling, 4EPS provides significant protection against hypertension and aortic aneurysm progression in mice, revealing a previously unrecognized protective role for a gut microbial metabolite in modulating renin-angiotensin system activity.
Authors
- Khuraijam Dhanachandra Singh (ORCID: https://orcid.org/0000-0003-0506-6896)
- Sadashiva S. Karnik (ORCID: https://orcid.org/0000-0003-0746-2753)
- Terri J. Harford (ORCID: https://orcid.org/0000-0001-6590-0673)
- Zaira Palomino Jara (ORCID: https://orcid.org/0000-0001-5440-3890)
- Kate Stenson (ORCID: https://orcid.org/0000-0002-4381-5213)
- Triveni R. Pardhi (ORCID: https://orcid.org/0000-0001-9872-6253)
- Tarun Ravi
- Ajay Zalavadia
- Russell Desnoyer (ORCID: https://orcid.org/0000-0003-2210-6810)
- Sathyamangla V. Naga Prasad
Institutions
- Cleveland Clinic Lerner College of Medicine (US)
Publication Details
- Journal
- Hypertension
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25364
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vanderbilt University
- National Institutes of Health