Clonal Profiles in a Li–Fraumeni Syndrome Patient With SHH Medulloblastoma: Clonal Evolution, Genomics, and Clinical Implications
The authors declare no conflicts of interest. Figure S2 Pedigree with autosomal dominant inheritance of early-onset cancers consistent with LFS. The proband (black square, arrow) presented with medulloblastoma at 9 years of age. NA: not analyzed; wt: wild type; tumor NOS: tumor not otherwise specified. Figure S3 Molecular characterization of medulloblastoma in a pediatric patient with a germline TP53 mutation across diagnosis and recurrences. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Authors
- Mireya Orozco‐Vela (ORCID: https://orcid.org/0009-0005-2701-1281)
- Jorge Román Corona‐Rivera (ORCID: https://orcid.org/0000-0002-4626-148X)
- Uriel Santana‐Bejarano (ORCID: https://orcid.org/0000-0002-4561-7069)
- Sinhué Alejandro Brukman‐Jiménez (ORCID: https://orcid.org/0000-0002-2715-7003)
- Víctor Ulises Rodríguez‐Machuca
- Lucina Bobadilla‐Morales (ORCID: https://orcid.org/0000-0002-7035-7924)
- Regina Navarro Martin del Campo
- Alfredo Corona‐Rivera
- Felipe de Jesús Bustos‐Rodríguez
- Héctor Velázquez‐Santana
- Juan Antonio Ramirez‐Corona
- Jose de Jesus Pérez‐Becerra
- Luis Ángel Arredondo‐Navarro
Institutions
- Universidad de Guadalajara (MX)
- Hospital Civil de Guadalajara (MX)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1002/1545-5017.70139
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00