Integrative multi-omics analyses identify PKD1 and SLC2A4 as genetically supported glycolysis-related candidate genes for rheumatoid arthritis
This integrative multi-omics MR framework supports an epigenetically mediated contribution of glycolysis-related regulation to RA susceptibility and nominates PKD1 and SLC2A4 as robust genetically supported candidate genes. These findings highlight methylation-linked transcriptional changes in glycolysis-related pathways implicated in RA and suggest potential biomarkers and therapeutic targets.
Authors
- Peijun Pan
- Lang Jin
- Guowei Qiu (ORCID: https://orcid.org/0000-0002-0555-0760)
- Songtao Sun
- Pengfei Xin (ORCID: https://orcid.org/0000-0002-1981-7497)
- Lin Zheng (ORCID: https://orcid.org/0000-0001-7597-4174)
- Jun Shen (ORCID: https://orcid.org/0009-0007-7362-1085)
- Yiwei Cheng (ORCID: https://orcid.org/0000-0003-1014-0325)
- Lianbo Xiao
- Jianye Wang
- Lei Ran
- Xinyu A
- Yanqin Bian
- Bo Xu
- Chenxin Gao
- Jun Xie
- Shaoqiang Pei
- Xirui Xu
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine (CN)
- Shanghai Institute of Applied Physics (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1691663
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- Gujarat Council on Science and Technology
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai University of Traditional Chinese Medicine