Signal Recognition Granule Receptor Beta Subunit Promotes Arrhythmogenic Remodeling in the Heart Failure Mice
<i>Srprb</i> knockdown improved ventricular remodeling and suppressed VAs in mice with heart failure, whereas its overexpression has opposite effects. These actions were mediated through regulation of endoplasmic reticulum stress and the TLR4/CaMKII/NF-κB pathway.
Authors
- H. Huang
- J S Zhang
- Yang Gong (ORCID: https://orcid.org/0000-0001-5294-6437)
- Wei Shuai (ORCID: https://orcid.org/0000-0002-5507-7369)
- Yucheng Pan
- Bin Kong
- Tao Chen
Institutions
- Cardiovascular Institute Hospital (JP)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1161/jaha.125.044103
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00