An interactive 3D atlas of gene expression in the mouse brain
The Allen Mouse Brain Atlas provides gene expression data for over 20,000 genes and has been extensively used in neuroscience. However, it is constrained by a resolution of 200 µm 3 . We improved this to 25 µm 3 for 4,083 genes by re-registering 401,660 sections to atlas space. From this, we produced an atlas with regions defined by shared molecular signatures and built an interactive online platform allowing exploration of gene expression patterns.
Authors
- Sharon C. Yates (ORCID: https://orcid.org/0000-0002-3001-8725)
- Trygve B. Leergaard (ORCID: https://orcid.org/0000-0001-5965-8470)
- Jan G. Bjaalie (ORCID: https://orcid.org/0000-0001-7899-906X)
- Archana Golla (ORCID: https://orcid.org/0000-0002-8665-3752)
- Simon McMullan (ORCID: https://orcid.org/0000-0002-9854-1029)
- Sébastien Piluso (ORCID: https://orcid.org/0000-0002-4419-1748)
- Maja Puchades (ORCID: https://orcid.org/0000-0002-4536-8197)
- Ingvild E. Bjerke (ORCID: https://orcid.org/0000-0002-2926-6836)
- Harry Carey (ORCID: https://orcid.org/0000-0002-4111-6259)
- Dickscheid Timo
- Daniel Keller
- Henry Markram
- Signý Benediktsdóttir
- Xiaoyun Gui
- Sophia Pieschnik
Institutions
- Forschungszentrum Jülich (DE)
- University of Oslo (NO)
- Jülich Aachen Research Alliance (DE)
- École Polytechnique Fédérale de Lausanne (CH)
- Macquarie University (AU)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-21
- DOI
- https://doi.org/10.64898/2026.01.20.700446
- Primary Topic
- Gene expression and cancer classification
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission