Synergistic anti-hepatoma effect of triptolide and quercetin <i>via</i> co-inhibition and interaction with Janus kinase and mammalian target of rapamycin signal pathway

Compared with a single drug, the specific metering combination of TP and quercetin has enhanced anti-tumor effects, mediated by inhibition of cell proliferation, inducing cell apoptosis and inhibiting migration/invasion. This synergistic effect is closely related to the simultaneous inhibition of signaling pathways JAK-STAT and mTOR concurrently.

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Publication Details

Journal
World Journal of Gastroenterology
Published
2026-01-22
DOI
https://doi.org/10.3748/wjg.v32.i4.114420
Primary Topic
Natural Compounds in Disease Treatment
Type
article
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article

Synergistic anti-hepatoma effect of triptolide and quercetin via co-inhibition and interaction with Janus kinase and mammalian target of rapamycin signal pathway

Wenyi Nie, Jiale Zhang, Hong-Xuan Tong, Li-Jie Jiang et al.
World Journal of Gastroenterology
Natural Compounds in Disease Treatment
article

Synergistic anti-hepatoma effect of triptolide and quercetin via co-inhibition and interaction with Janus kinase and mammalian target of rapamycin signal pathway

Wenyi Nie, Jiale Zhang, Hong-Xuan Tong, Li-Jie Jiang, Jing-Qing Hu, Tao Lu
article en

Abstract

Compared with a single drug, the specific metering combination of TP and quercetin has enhanced anti-tumor effects, mediated by inhibition of cell proliferation, inducing cell apoptosis and inhibiting migration/invasion. This synergistic effect is closely related to the simultaneous inhibition of signaling pathways JAK-STAT and mTOR concurrently.

World Journal of GastroenterologyVol. 32(4)
Xinjiang Medical University (CN), Beijing University of Chinese Medicine (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), China Rural Technology Development Center (CN), Chinese Academy of Science and Technology for Development (CN)
Good health and well-being
Openalex Percentile: Top 80%
Natural Compounds in Disease Treatment
DOIOpen Access PDFOpenAlex
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